AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families.

@article{Thiselton2008AKT1IA,
  title={AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families.},
  author={Dawn L. Thiselton and Vladimir I. Vladimirov and Po-Hsiu Kuo and Joseph L. McClay and Brandon K Wormley and Ayman H. Fanous and Francis Anthony O'Neill and Dermot Walsh and Edwin J. C. G. van den Oord and Kenneth S. Kendler and Brien P. Riley},
  journal={Biological psychiatry},
  year={2008},
  volume={63 5},
  pages={449-57}
}
BACKGROUND The phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction pathway is critical to cell growth and survival. In vitro functional studies indicate that the candidate schizophrenia susceptibility gene DTNBP1 influences AKT signaling to promote neuronal viability. The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients. METHODS The association of DTNBP1 in the Irish Study of High… CONTINUE READING
59 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

Similar Papers

Loading similar papers…