AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.

@article{Habib2017AKT1HD,
  title={AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.},
  author={Tanwir Habib and Ameera Sadoun and Nancy Nader and Shigeru Suzuki and Wei Liu and Puthen V. Jithesh and Tomoshige Kino},
  journal={Molecular and cellular endocrinology},
  year={2017},
  volume={439},
  pages={431-443}
}
Glucocorticoids are important therapeutic compounds for acute lymphoblastic leukemia (ALL). AKT1 or the protein kinase B is frequently activated in ALL, and contributes to the development of glucocorticoid resistance. We examined impact of AKT1 on glucocorticoid receptor (GR)-induced transcriptional activity in cooperation with phospho-serine/threonine… CONTINUE READING