AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

@article{Juntilla2010AKT1AA,
  title={AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.},
  author={Marisa M. Juntilla and Vineet D. Patil and Marco Calamito and Rohan P. Joshi and Morris J Birnbaum and Gary A Koretzky},
  journal={Blood},
  year={2010},
  volume={115 20},
  pages={4030-8}
}
Although AKT is essential for multiple cellular functions, the role of this kinase family in hematopoietic stem cells (HSCs) is unknown. Thus, we analyzed HSC function in mice deficient in the 2 isoforms most highly expressed in the hematopoietic compartment, AKT1 and AKT2. Although loss of either isoform had only a minimal effect on HSC function, AKT1/2 double-deficient HSCs competed poorly against wild-type cells in the development of myeloid and lymphoid cells in in vivo reconstitution… CONTINUE READING

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