AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease.

@article{Livens2007AKTsensitiveOI,
  title={AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease.},
  author={Jean-Charles Li{\'e}vens and Magali Ich{\'e} and Monique Laval and Catherine Faivre-Sarrailh and Serge Birman},
  journal={Human molecular genetics},
  year={2007},
  volume={17 6},
  pages={
          882-94
        }
}
Huntington's disease (HD) is caused by an extended polyglutamine (polyQ) tract in the Huntingtin protein. Neuronal and glial dysfunction precedes the neurodegeneration and appears to be the primary cause for the early symptoms in HD. In recent years, development of Drosophila models of polyQ-related diseases facilitated research of candidate rescuer genes. In most cases, analysis in Drosophila was performed by assessing toxicity on retinal and/or brain neurons. However, none of the potential… CONTINUE READING

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