AKT regulates NPM dependent ARF localization and p53mut stability in tumors

@inproceedings{Hamilton2014AKTRN,
  title={AKT regulates NPM dependent ARF localization and p53mut stability in tumors},
  author={Garth Hamilton and Aswin George Abraham and Jennifer P Morton and Oliver Sampson and Dafni Eleftheria Pefani and Svetlana V. Khoronenkova and Anna M. Grawenda and Angelos Papaspyropoulos and Nigel Balfour Jamieson and Colin Mckay and Owen James Sansom and Grigory L Dianov and Eric O'Neill},
  booktitle={Oncotarget},
  year={2014}
}
Nucleophosmin (NPM) is known to regulate ARF subcellular localization and MDM2 activity in response to oncogenic stress, though the precise mechanism has remained elusive. Here we describe how NPM and ARF associate in the nucleoplasm to form a MDM2 inhibitory complex. We find that oligomerization of NPM drives nucleolar accumulation of ARF. Moreover, the formation of NPM and ARF oligomers antagonizes MDM2 association with the inhibitory complex, leading to activation of MDM2 E3-ligase activity… CONTINUE READING
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