AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis.

@article{Roy2002AKTPO,
  title={AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis.},
  author={Hemant K Roy and Bola F Olusola and Dahn L. Clemens and William J Karolski and Anne Ratashak and Henry T. Lynch and Thomas C. Smyrk},
  journal={Carcinogenesis},
  year={2002},
  volume={23 1},
  pages={201-5}
}
The inhibition of apoptosis is a critical event in the development of colorectal malignancies, although the mechanism(s) remain incompletely understood. The anti-apoptotic proto-oncogene, AKT, has been implicated in the molecular pathogenesis of a variety of human malignancies; however, no data exist on the role of AKT in colon carcinogenesis. We therefore evaluated the presence of AKT in human and experimental colon neoplasms by immunohistochemistry. Normal colonic mucosa and hyperplastic… CONTINUE READING