AKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage


Post-translational modifications of core histones affect various cellular processes, primarily through transcription. However, their relationship with the termination of transcription has remained largely unknown. In this study, we show that DNA damage-activated AKT phosphorylates threonine 45 of core histone H3 (H3-T45). By genome-wide chromatin… (More)
DOI: 10.1093/nar/gkv176