AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.

@article{Bogush2007AKTAC,
  title={AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.},
  author={Alexey I. Bogush and Steve Pedrini and Joshua Pelta-Heller and Tung Chan and Qian Yang and Zixu Mao and Emily M Sluzas and Tracy A. Gieringer and Michelle E Ehrlich},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 10},
  pages={7352-9}
}
Mature striatal medium size spiny neurons express the dopamine and cyclic AMP-regulated phosphoprotein, 32 kDa (DARPP-32), but little is known about the mechanisms regulating its levels or the specification of fully differentiated neuronal subtypes. Cell extrinsic molecules that increase DARPP-32 mRNA and/or protein levels include brain-derived neurotrophic factor (BDNF), retinoic acid, and estrogen. DARPP-32 induction by BDNF in vitro requires phosphatidylinositide 3-kinase (PI3K), but… CONTINUE READING