AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

  title={AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer},
  author={Joanna C Chan and Katherine M. Hannan and Kim Riddell and Pui Y. Ng and Abigail Peck and Rachel S. Lee and Sandy S. C. Hung and Megan Victoria Astle and Megan Bywater and Meaghan Wall and Gretchen Poortinga and Katarzyna Jastrzebski and Karen E. Sheppard and Brian A. Hemmings and Michael N. Hall and Ricky W. Johnstone and Grant A. McArthur and Ross D. Hannan and Richard B. Pearson},
  journal={Science Signaling},
  pages={ra56 - ra56}
In addition to promoting translation, AKT also stimulates protein synthesis and cell growth by enhancing ribosome biogenesis. Building the Building Blocks Ribosomes translate mRNA into protein, and the activity of signaling pathways that promote ribosome formation (or biogenesis) is often increased in cancer cells, which have high rates of protein synthesis and cell growth. Thus, each step of ribosome biogenesis can limit cell growth, including the synthesis of ribosomal RNA (rRNA), which… 

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