AKT Inhibitors Promote Cell Death in Cervical Cancer through Disruption of mTOR Signaling and Glucose Uptake

@inproceedings{Rashmi2014AKTIP,
  title={AKT Inhibitors Promote Cell Death in Cervical Cancer through Disruption of mTOR Signaling and Glucose Uptake},
  author={Ramachandran Rashmi and Carl Deselm and Cynthia Helms and Anne M Bowcock and Buck E Rogers and Janet S Rader and Perry Grigsby and Julie K. Schwarz},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND PI3K/AKT pathway alterations are associated with incomplete response to chemoradiation in human cervical cancer. This study was performed to test for mutations in the PI3K pathway and to evaluate the effects of AKT inhibitors on glucose uptake and cell viability. EXPERIMENTAL DESIGN Mutational analysis of DNA from 140 pretreatment tumor… CONTINUE READING