AKT-1 Regulates DNA-Damage-Induced Germline Apoptosis in C. elegans

@article{Quevedo2007AKT1RD,
  title={AKT-1 Regulates DNA-Damage-Induced Germline Apoptosis in C. elegans},
  author={C. Torres Quevedo and David R Kaplan and W. Brent Derry},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={286-292}
}
The cellular response to genotoxic stress involves the integration of multiple prosurvival and proapoptotic signals that dictate whether a cell lives or dies. In mammals, AKT/PKB regulates cell survival by modulating the activity of several apoptotic proteins, including p53. In Caenorhabditis elegans, akt-1 and akt-2 regulate development in response to environmental cues by controlling the FOXO transcription factor daf-16, but the role of these genes in regulating p53-dependent apoptosis is not… CONTINUE READING
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