AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival

@inproceedings{Romorini2016AKTGSK3SP,
  title={AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival},
  author={Leonardo Romorini and Ximena Garate and Gabriel Neiman and Carlos Luzzani and Ver{\'o}nica Alejandra Furmento and Alejandra S Guberman and Gustavo Emilio Sevlever and Mar{\'i}a {\'E}lida Scassa and Santiago Gabriel Miriuka},
  booktitle={Scientific reports},
  year={2016}
}
Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (PSC) that can differentiate into a wide range of specialized cells. Basic fibroblast growth factor is essential for PSC survival, stemness and self-renewal. PI3K/AKT pathway regulates cell viability and apoptosis in many cell types. Although it has been demonstrated that PI3K/AKT activation by bFGF is relevant for PSC stemness maintenance its role on PSC survival remains elusive. In this study we… CONTINUE READING
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