AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program


Basal-like breast cancer (BLBC) is associated with high-grade, distant metastasis and poor prognosis. Elucidating the determinants of aggressiveness in BLBC may facilitate the development of novel interventions for this challenging disease. In this study, we show that aldo-keto reductase 1 member B1 (AKR1B1) overexpression highly correlates with BLBC and… (More)
DOI: 10.1084/jem.20160903


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