AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa.

@article{Bajpai2006AKAP3SB,
  title={AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa.},
  author={Malini Bajpai and Sarah E Fiedler and Zaohua Huang and Srinivasan Vijayaraghavan and Gary E. Olson and Gabriel Livera and Marco Conti and Daniel J J Carr},
  journal={Biology of reproduction},
  year={2006},
  volume={74 1},
  pages={
          109-18
        }
}
Cyclic AMP plays an important role in regulating sperm motility and acrosome reaction through activation of cAMP-dependent protein kinase A (PKA). Phosphodiesterases (PDEs) modulate the levels of cyclic nucleotides by catalyzing their degradation. Although PDE inhibitors specific to PDE1 and PDE4 are known to alter sperm motility and capacitation in humans, little is known about the role or subcellular distribution of PDEs in spermatozoa. The localization of PKA is regulated by A-kinase… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 1 EXCERPT