AKAP150-anchored PKA activity is important for LTD during its induction phase.

@article{Lu2008AKAP150anchoredPA,
  title={AKAP150-anchored PKA activity is important for LTD during its induction phase.},
  author={Yuan George Lu and Mingxu Zhang and Indra A. Lim and Duane D. Hall and Margaret Allen Margaret Allen and Yuliya V. Medvedeva and G Stanley McKnight and Yuriy M Usachev and Johannes W Hell},
  journal={The Journal of physiology},
  year={2008},
  volume={586 17},
  pages={
          4155-64
        }
}
Protein kinase A (PKA) is thought to tonically maintain an enhanced level of postsynaptic AMPA receptor responses. Injection of PKA inhibitory peptides leads to a run-down of AMPA receptor responses and prevents long-term depression (LTD). This run-down of AMPA receptor activity was proposed to occlude a further reduction that would otherwise constitute LTD. PKA is recruited to postsynaptic sites by the A kinase anchor protein AKAP150. We found that LTD was strongly impaired in acute… CONTINUE READING
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