AKAP15 anchors cAMP-dependent protein kinase to brain sodium channels.

@article{Tibbs1998AKAP15AC,
  title={AKAP15 anchors cAMP-dependent protein kinase to brain sodium channels.},
  author={Victoria C. Tibbs and Perry Clayton Gray and William A. Catterall and Brian Joseph Patrick Murphy},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 40},
  pages={
          25783-8
        }
}
The voltage-sensitive sodium channel is regulated by cAMP-dependent protein kinase (PKA) phosphorylation. Using purified preparations of rat brain sodium channels, we have shown that the alpha subunit was phosphorylated by a co-purifying protein kinase. The co-purifying kinase was stimulated by cAMP and phosphorylated PKA substrate peptides. Both the regulatory and catalytic subunits of PKA were detected by immunoblotting in purified sodium channel preparations. Bound PKA was immunoprecipitated… CONTINUE READING
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Dopaminergic modulation of voltage-gated Na+ current in rat hippocampal neurons requires anchoring of cAMP-dependent protein kinase.

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  • 1999
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