AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice

@article{Youngblood2019AK002AH,
  title={AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice},
  author={Bradford A. Youngblood and Emily C. Brock and John K Y Leung and Rustom Falahati and P. Bryce and J. Bright and J. Williams and L. Shultz and D. Greiner and M. Brehm and Christopher Bebbington and N. Toma{\vs}evi{\'c}},
  journal={International Archives of Allergy and Immunology},
  year={2019},
  volume={180},
  pages={102 - 91}
}
  • Bradford A. Youngblood, Emily C. Brock, +9 authors N. Tomašević
  • Published 2019
  • Chemistry, Medicine
  • International Archives of Allergy and Immunology
  • Introduction: Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on mast cells, eosinophils and, at a lower extent, basophils. When engaged with an antibody, Siglec-8 can induce apoptosis of activated eosinophils and inhibit mast cell activation. AK002 is a humanized, non-fucosylated IgG1 anti-Siglec-8 antibody… CONTINUE READING
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