AJI9561, a new cytotoxic benzoxazole derivative produced by Streptomyces sp.

  title={AJI9561, a new cytotoxic benzoxazole derivative produced by Streptomyces sp.},
  author={Seiichi Sato and Takayuki Kajiura and Mai Noguchi and Kazushige Takehana and Toyoaki Kobayashi and Takashi Tsuji},
  journal={The Journal of antibiotics},
  volume={54 1},
(Traders) 1.0%, yeast extract 0.1%, and CaCO3 0.2% (pH 7.2). The fermentation was carried out at 28°C on a rotary shaker (180 rpm) for 96 hours. The culture broth of Streptomyces sp. AJ9561 (5 liters) was filtered to obtain mycelium, which was extracted with acetone (3 liters) at room temperature. The extract was concentrated in vacuo to an aqueous suspension, which was extracted with EtOAc (500 mix3). The organic layers were combined and dried in vacuo to give brown oil (3.5 g). The residue… CONTINUE READING
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