AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies

Abstract

APS1/APECED patients are defined by defects in the autoimmune regulator (AIRE) that mediates central T cell tolerance to many self-antigens. AIRE deficiency also affects B cell tolerance, but this is incompletely understood. Here we show that most APS1/APECED patients displayed B cell autoreactivity toward unique sets of approximately 100 self-proteins… (More)
DOI: 10.1016/j.cell.2016.06.024

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@inproceedings{Meyer2016AIREDeficientPH, title={AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies}, author={Steffen Meyer and Martin Woodward and Christina Hertel and Philip Vlaicu and Yasmin Haque and Jaanika K{\"a}rner and Annalisa Macagno and Shimobi C. Onuoha and Dmytro Fishman and Hedi Peterson and Kaja Metsk{\"{u}la and Raivo Uibo and Kirsi J{\"a}ntti and Kati Hokynar and Anette S.B. Wolff and Antonella Meloni and Nicolas Kluger and Eystein S. Husebye and Katarina Trebusak Podkrajsek and Tadej Battelino and Nina Bratani{\vc} and Aleksandr Peet and Kai J. E. Krohn and Annamari Ranki and P{\"a}rt Peterson and Kai Kisand and Adrian C. Hayday}, booktitle={Cell}, year={2016} }