AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation

@inproceedings{Schimmack2014AIPAC,
  title={AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation},
  author={Gisela Schimmack and Andrea C. Eitelhuber and Michelle Vincendeau and Katrin Demski and Hisaaki Shinohara and Tomohiro Kurosaki and Daniel Krappmann},
  booktitle={Cell Communication and Signaling},
  year={2014}
}
The CARMA1-BCL10-MALT1 (CBM) complex bridges T cell receptor (TCR) signaling to the canonical IκB kinase (IKK)/NF-κB pathway. The CBM complex constitutes a signaling cluster of more than 1 Mio Dalton. Little is known about factors that facilitate the rapid assembly and maintenance of this dynamic higher order complex. Here, we report the novel interaction of the aryl hydrocarbon receptor (AHR) interacting protein (AIP) and the molecular scaffold protein CARMA1. In T cells, transient binding of… CONTINUE READING

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