AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

@article{Pierini2012AIM2ASCTC,
  title={AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages},
  author={Roberto Pierini and Carole Juruj and Magali Perret and Camtu L Jones and P E Mangeot and David S Weiss and Thomas Henry},
  journal={Cell Death and Differentiation},
  year={2012},
  volume={19},
  pages={1709-1721}
}
The inflammasome is a signalling platform leading to caspase-1 activation. Caspase-1 causes pyroptosis, a necrotic-like cell death. AIM2 is an inflammasome sensor for cytosolic DNA. The adaptor molecule ASC mediates AIM2-dependent caspase-1 activation. To date, no function besides caspase-1 activation has been ascribed to the AIM2/ASC complex. Here, by comparing the effect of gene inactivation at different levels of the inflammasome pathway, we uncovered a novel cell death pathway activated in… CONTINUE READING
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