AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration.

@article{Autieri2003AIF1IA,
  title={AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration.},
  author={Michael V. Autieri and Sheri E. Kelemen and Karl W Wendt},
  journal={Circulation research},
  year={2003},
  volume={92 10},
  pages={1107-14}
}
Development of vascular restenosis is a multifaceted process characterized by migration and proliferation of vascular smooth muscle cells (VSMCs), resulting in loss of lumen diameter. Characterization of proteins that mediate this process is essential in our understanding of the pathogenesis of arterial injury. Allograft inflammatory factor-1 (AIF-1) is a cytoplasmic, calcium-binding protein that is expressed in VSMCs by allograft and balloon angioplasty injury. AIF-1 is not present in cultured… CONTINUE READING

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