Two clinical cases of HIV-infected pregnant women are presented: One with declared AIDS and the other a symptomless carrier. The clinical management of these cases are described; that is, the resolution of the delivery and the clinical measures implemented during their hospitalization. Both, the potential ways of propagating the infection among the health workers as well as the universal precautions which must be taken in order to avoid the risk of infection are discussed. The perinatal transmission of the HIV virus and the possible risk factors are also studied in this presentation. In the heterosexual relations of the couples infected with HIV are considered important their associated risk factors. It appears that education is the primary factor to prevent the infection in obs-gyn patients, more than obtaining resources to do massive serological tests on them.