AIDS across Europe, 1994–98: the EuroSIDA study

@article{Mocroft2000AIDSAE,
  title={AIDS across Europe, 1994–98: the EuroSIDA study},
  author={Amanda Mocroft and Christine Katlama and Am Johnson and Christian Pradier and F Antunes and Fiona Mulcahy and Antonio M. Chiesi and Andrew N Phillips and Ole Kirk and J D Lundgren},
  journal={The Lancet},
  year={2000},
  volume={356},
  pages={291-296}
}
The changing pattern of AIDS-defining illnesses with the introduction of highly active antiretroviral therapy (HAART)in a London clinic.
TLDR
The incidence of most ADIs has decreased over the last 9 years and a striking reduction in the inci-dence of PCP and Kaposi's sarcoma since 1996 can be attributed to the use of combination ART and particularly HAART.
Changes in the cause of death among HIV positive subjects across Europe: results from the EuroSIDA study
TLDR
The proportion of pre-AIDS deaths increased from 1994 to 2001; however, the incidence of pre -AIDS deaths and deaths overall declined; therefore, it is essential to continue to monitor all causes of mortality to identify changes.
Non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy.
TLDR
The incidence of NHL among HIV-infected patients has decreased significantly after the introduction of HAART, and the decline was most pronounced for PBL.
AIDS-defining illnesses: a comparison between before and after commencement of highly active antiretroviral therapy (HAART).
TLDR
ADIs can still present after the initiation of successful HAART especially in those with CD4 counts below 100 cells/mm(3), thus increased awareness on the management of these illnesses is warranted especially in the months following HAART.
Differential improvement in survival among patients with AIDS after the introduction of HAART
TLDR
Substantial improvements in survival after the introduction of HAART were found for all PWA but varied by specific ADIs and the degree of immunosuppression, and was marked during the late HAART period across all HIV transmission categories, including intravenous drug use.
The Clinical Benefits of Antiretroviral Therapy in Severely Immunocompromised HIV-1-Infected Patients with and without Complete Viral Suppression
TLDR
In patients with ongoing severe immunosuppression, cART was associated with significant clinical benefits in patients with suboptimalVirological control or virological failure.
Opportunistic Infections and Other AIDS-defining Illnesses in Poland in 2000–2002
TLDR
Fungal infections and tuberculosis were the most common OIs in HIV+ patients in Poland five years after the introduction of HAART, and the incidence of ADIs had declined.
The incidence of AIDS-defining illnesses at a current CD4 count ≥ 200 cells/μL in the post-combination antiretroviral therapy era.
  • A. Mocroft, H. Furrer, J. Lundgren
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2013
TLDR
The incidence of ADIs was higher in patients virologically suppressed on combination antiretroviral therapy, suggesting that immune reconstitution is not complete until the CD4 increases to >750 cells/µL.
The EuroSIDA study: 25 years of scientific achievements
TLDR
In celebration of the EuroSIDA study’s 25th anniversary, this article aims to summarize key scientific findings and outline current and future scientific focus areas.
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