AIDS across Europe, 1994–98: the EuroSIDA study
@article{Mocroft2000AIDSAE, title={AIDS across Europe, 1994–98: the EuroSIDA study}, author={Amanda Mocroft and Christine Katlama and Am Johnson and Christian Pradier and F Antunes and Fiona Mulcahy and Antonio M. Chiesi and Andrew N Phillips and Ole Kirk and J D Lundgren}, journal={The Lancet}, year={2000}, volume={356}, pages={291-296} }
479 Citations
The changing pattern of AIDS-defining illnesses with the introduction of highly active antiretroviral therapy (HAART)in a London clinic.
- MedicineThe Journal of infection
- 2001
The incidence of most ADIs has decreased over the last 9 years and a striking reduction in the inci-dence of PCP and Kaposi's sarcoma since 1996 can be attributed to the use of combination ART and particularly HAART.
Decline in the AIDS and death rates in the EuroSIDA study: an observational study
- MedicineThe Lancet
- 2003
Changes in the cause of death among HIV positive subjects across Europe: results from the EuroSIDA study
- Medicine, Political ScienceAIDS
- 2002
The proportion of pre-AIDS deaths increased from 1994 to 2001; however, the incidence of pre -AIDS deaths and deaths overall declined; therefore, it is essential to continue to monitor all causes of mortality to identify changes.
Non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy.
- MedicineBlood
- 2001
The incidence of NHL among HIV-infected patients has decreased significantly after the introduction of HAART, and the decline was most pronounced for PBL.
AIDS-defining illnesses: a comparison between before and after commencement of highly active antiretroviral therapy (HAART).
- Medicine, BiologyCurrent HIV research
- 2007
ADIs can still present after the initiation of successful HAART especially in those with CD4 counts below 100 cells/mm(3), thus increased awareness on the management of these illnesses is warranted especially in the months following HAART.
Differential improvement in survival among patients with AIDS after the introduction of HAART
- MedicineAIDS care
- 2007
Substantial improvements in survival after the introduction of HAART were found for all PWA but varied by specific ADIs and the degree of immunosuppression, and was marked during the late HAART period across all HIV transmission categories, including intravenous drug use.
The Clinical Benefits of Antiretroviral Therapy in Severely Immunocompromised HIV-1-Infected Patients with and without Complete Viral Suppression
- Medicine, BiologyAntiviral therapy
- 2012
In patients with ongoing severe immunosuppression, cART was associated with significant clinical benefits in patients with suboptimalVirological control or virological failure.
Opportunistic Infections and Other AIDS-defining
Illnesses in Poland in 2000–2002
- Medicine, BiologyInfection
- 2006
Fungal infections and tuberculosis were the most common OIs in HIV+ patients in Poland five years after the introduction of HAART, and the incidence of ADIs had declined.
The incidence of AIDS-defining illnesses at a current CD4 count ≥ 200 cells/μL in the post-combination antiretroviral therapy era.
- MedicineClinical infectious diseases : an official publication of the Infectious Diseases Society of America
- 2013
The incidence of ADIs was higher in patients virologically suppressed on combination antiretroviral therapy, suggesting that immune reconstitution is not complete until the CD4 increases to >750 cells/µL.
The EuroSIDA study: 25 years of scientific achievements
- MedicineHIV medicine
- 2019
In celebration of the EuroSIDA study’s 25th anniversary, this article aims to summarize key scientific findings and outline current and future scientific focus areas.
References
SHOWING 1-10 OF 32 REFERENCES
Changing incidence of AIDS‐defining illnesses in the era of antiretroviral combination therapy
- MedicineAIDS
- 1997
The incidence of AIDS-defining events in patients with advanced HIV infection at Frankfurt University Hospital has declined by more than 70% from 1992 to 1996, with a trend for malignancies and single opportunistic infections, with the exception of mycobacterial diseases.
Changes in use of antiretroviral therapy in regions of Europe over time
- Medicine, Political ScienceAIDS
- 1998
Use of antiretroviral therapy in Europe has changed dramatically towards combination treatment in the last few years, and regional differences in use of antifiltration therapy have decreased, and by September 1997 only minor differences remained.
Impact of protease inhibitors on AIDS‐defining events and hospitalizations in 10 French AIDS reference centres
- Medicine, Political ScienceAIDS
- 1997
This study supports the extensive use of HAART in HIV-infected patients and shows a clear benefit to early HAART with a drop in hospitalization days, new AIDS cases, and deaths.
Changes in AIDS-defining illnesses in a London Clinic, 1987-1998.
- MedicineJournal of acquired immune deficiency syndromes
- 1999
There was a considerable decline in AIDS-defining illnesses during 1996 and 1997, coinciding with the rapid development of new antiretroviral treatments and combinations of treatment.
Opportunistic infections occurring during highly active antiretroviral treatment
- Medicine, BiologyAIDS
- 1998
In patients at high risk of developing an opportunistic infection prior to the institution of a HAART regimen, prophylaxis should not be discontinued during the first 2 months of treatment, and maintenance therapy should be carried on despite a significant increase in the CD4 cell count.
Regional differences in use of antiretroviral agents and primary prophylaxis in 3122 European HIV-infected patients. EuroSIDA Study Group.
- Medicine, BiologyJournal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
- 1997
ARV therapy was more frequently used among patients from southern and central Europe as compared with patients from northern Europe, especially among patients with CD4 counts >200 cells/microl, and antifungal therapies are used differently in different parts of Europe.
AIDS diagnoses at higher CD4 counts in Australia following the introduction of highly active antiretroviral treatment.
- Medicine, Political ScienceAIDS
- 1999
There has been an increase in the CD4 count at AIDS diagnosis for most AIDS-defining illnesses in Australia coincident with the widespread availability of HAART.
Rapid Change in the Use of Antiretroviral Agents and Improvement in a Population of HIV-Infected Patients: France, 1995 to 1997
- Medicine, Biology
- 1998
Over this 3-year period, physicians prescribed antiretroviral treatments more and more frequently, and triple combination therapy with PI is now common practice in France.
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
- MedicineThe New England journal of medicine
- 1998
The recent declines in morbidity and mortality due to AIDS are attributable to the use of more intensive antiretroviral therapies.
Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy
- Medicine, BiologyThe Lancet
- 1997