AIDA (all-trans retinoic acid + idarubicin) in newly diagnosed acute promyelocytic leukemia: a Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) pilot study.

@article{Avvisati1996AIDAR,
  title={AIDA (all-trans retinoic acid + idarubicin) in newly diagnosed acute promyelocytic leukemia: a Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) pilot study.},
  author={Giuseppe Avvisati and Francesco Lo Coco and Daniela Diverio and Michele Falda and Felicetto Ferrara and Mario Lazzarino and Domenico Russo and Maria Concetta Petti and Franco Mandelli},
  journal={Blood},
  year={1996},
  volume={88 4},
  pages={1390-8}
}
From March 1993 to October 1993, 20 consecutive, newly diagnosed acute promyelocytic leukemia (APL) patients from 13 Italian institutions entered in a pilot study named AIDA, combining all-trans retinoic acid (ATRA) with idarubicin (IDA). ATRA was administered orally beginning on the first day of induction at the dosage of 45 mg/m2/d until complete remission (CR), whereas IDA was administered intravenously at the dosage of 12 mg/m2/d on days 2, 4, 6, and 8 of the induction. Patients who… CONTINUE READING
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In vitro ad in vivo regulation of adhesion molecules in acute promyelocytic leukemia ( APL ) cells by the PML - RARol gene product and all - trans - retinoic acid ( ATRA )

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