AID targeting is dependent on RNA polymerase II pausing.

  title={AID targeting is dependent on RNA polymerase II pausing.},
  author={Amy L. Kenter},
  journal={Seminars in immunology},
  volume={24 4},
Activation induced deaminase (AID) is globally targeted to immunoglobulin loci, preferentially focused to switch (S) regions and variable (V) regions, and prone to attack hotspot motifs. Nevertheless, AID deamination is not exclusive to Ig loci and the rules regulating AID targeting remain unclear. Transcription is critically required for class switch recombination and somatic hypermutation. Here, I consider the unique features associated with S region transcription leading to RNA polymerase II… CONTINUE READING


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