AID from bony fish catalyzes class switch recombination

  title={AID from bony fish catalyzes class switch recombination},
  author={Vasco M. Barreto and Qiang Pan-Hammarstrom and Yaofeng Zhao and Lennart Hammarstrom and Ziva Misulovin and Michel C. Nussenzweig},
  journal={The Journal of Experimental Medicine},
  pages={733 - 738}
Class switch recombination was the last of the lymphocyte-specific DNA modification reactions to appear in the evolution of the adaptive immune system. It is absent in cartilaginous and bony fish, and it is common to all tetrapods. Class switching is initiated by activation-induced cytidine deaminase (AID), an enzyme expressed in cartilaginous and bony fish that is also required for somatic hypermutation. Fish AID differs from orthologs found in tetrapods in several respects, including its… CONTINUE READING
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