AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.

@article{Chesi2008AIDdependentAO,
  title={AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.},
  author={Marta Chesi and Davide F Robbiani and Michael Sebag and Wee Joo Chng and Maurizio Affer and Rodger Tiedemann and Riccardo Valdez and Stephen E. Palmer and Stephanie S Haas and Alexander Stewart and Rafael Fonseca and Richard Kremer and Giorgio Cattoretti and Peter Leif Bergsagel},
  journal={Cancer cell},
  year={2008},
  volume={13 2},
  pages={167-80}
}
By misdirecting the activity of Activation-Induced Deaminase (AID) to a conditional MYC transgene, we have achieved sporadic, AID-dependent MYC activation in germinal center B cells of Vk*MYC mice. Whereas control C57BL/6 mice develop benign monoclonal gammopathy with age, all Vk*MYC mice progress to an indolent multiple myeloma associated with the biological and clinical features highly characteristic of the human disease. Furthermore, antigen-dependent myeloma could be induced by immunization… CONTINUE READING