AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

@article{Kovalchuk2007AIDdeficientBT,
  title={AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements},
  author={Alexander Kovalchuk and Wendy Dubois and Elizabeth B. Mushinski and Nicole McNeil and C. Hirt and C. F. Qi and Zhaoyang Li and Siegfried Janz and T. Honjo and Masamichi Muramatsu and Thomas Ried and Timothy W. Behrens and Michael L Potter},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={2989 - 3001}
}
Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) class switch recombination and somatic hypermutation, and has also been implicated in translocations between Ig switch regions and c-Myc in plasma cell tumors in mice. We asked if AID is required for accelerated tumor development in pristane-treated Bcl-xL transgenic BALB/c mice deficient in AID (pBxAicda-/-). pBxAicda-/- mice developed tumors with a lower frequency (24 vs. 62%) and a longer mean latency (108 vs. 36… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Constitutive histone H 2 AX phosphorylation and ATM activation , the reporters of DNA damage by endogenous oxidants

  • F. Traganos, Z. Darzynkiewicz
  • Cell Cycle .
  • 2006

Diff erences in the peritoneal response to pristane in BALB / cAnPt and BALB / cJ mice

  • F. Aloisi, R. Pujol-Borrell
  • Curr . Top . Microbiol . Immunol .
  • 2006

Similar Papers

Loading similar papers…