AID and Apobec3G haphazard deamination and mutational diversity

@article{Jaszczur2012AIDAA,
  title={AID and Apobec3G haphazard deamination and mutational diversity},
  author={Malgorzata Jaszczur and Jeffrey G. Bertram and Phuong Quoc Pham and Matthew D. Scharff and Myron F. Goodman},
  journal={Cellular and Molecular Life Sciences},
  year={2012},
  volume={70},
  pages={3089-3108}
}
Activation-induced deoxycytidine deaminase (AID) and Apobec 3G (Apo3G) cause mutational diversity by initiating mutations on regions of single-stranded (ss) DNA. Expressed in B cells, AID deaminates C → U in actively transcribed immunoglobulin (Ig) variable and switch regions to initiate the somatic hypermutation (SHM) and class switch recombination (CSR) that are essential for antibody diversity. Apo3G expressed in T cells catalyzes C deaminations on reverse transcribed cDNA causing HIV-1… CONTINUE READING
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