AID Recognizes Structured DNA for Class Switch Recombination.

  title={AID Recognizes Structured DNA for Class Switch Recombination.},
  author={Qi Qiao and Li Wang and Fei-Long Meng and Joyce K. Hwang and Frederick W Alt and Hao Wu},
  journal={Molecular cell},
  volume={67 3},
Activation-induced cytidine deaminase (AID) initiates both class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. Mechanisms of AID targeting and catalysis remain elusive despite its critical immunological roles and off-target effects in tumorigenesis. Here, we produced active human AID and revealed its preferred recognition and deamination of structured substrates. G-quadruplex (G4)-containing substrates mimicking the mammalian immunoglobulin switch… CONTINUE READING
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Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

  • V. Shivarov, R. Shinkura, T. Honjo
  • Nat. Struct. Mol. Biol
  • 2017

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