AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.

@article{Rada2002AIDGFPCP,
  title={AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.},
  author={Cristina Rada and John M. Jarvis and C{\'e}sar Milstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 10},
  pages={
          7003-8
        }
}
Somatic hypermutation generates variants of antibody genes and underpins the affinity maturation of antibodies. It is restricted to the V-gene segments, and although it decays exponentially toward the 3'end, it includes recognizable hot spots. Although the detailed mechanism of hypermutation remains elusive, the process may take place in two separate stages, preferentially targeting G/Cs in the first and A/Ts in the second stage. It seems that MSH2 is involved in the second stage, and that… CONTINUE READING

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Sequence defined mutations Clone Sequences Total bases Deletions Point mutation Mutation rate

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