AID Enzymatic Activity Is Inversely Proportional to the Size of Cytosine C5 Orbital Cloud

@inproceedings{Rangam2012AIDEA,
  title={AID Enzymatic Activity Is Inversely Proportional to the Size of Cytosine C5 Orbital Cloud},
  author={Gopinath Rangam and K. Schmitz and Alexander J. A. Cobb and Svend K. Petersen-Mahrt},
  booktitle={PloS one},
  year={2012}
}
Activation induced deaminase (AID) deaminates cytosine to uracil, which is required for a functional humoral immune system. Previous work demonstrated, that AID also deaminates 5-methylcytosine (5 mC). Recently, a novel vertebrate modification (5-hydroxymethylcytosine - 5 hmC) has been implicated in functioning in epigenetic reprogramming, yet no molecular pathway explaining the removal of 5 hmC has been identified. AID has been suggested to deaminate 5 hmC, with the 5 hmU product being… CONTINUE READING
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