AID Biology: A pathological and clinical perspective.

  title={AID Biology: A pathological and clinical perspective.},
  author={Meenal Choudhary and Anubhav Tamrakar and Amit Kumar Singh and Monika Jain and Ankit Jaiswal and Prashant Kodgire},
  journal={International reviews of immunology},
  volume={37 1},
Activation-induced cytidine deaminase (AID), primarily expressed in activated mature B lymphocytes in germinal centers, is the key factor in adaptive immune response against foreign antigens. AID is responsible for producing high-affinity and high-specificity antibodies against an infectious agent, through the physiological DNA alteration processes of antibody genes by somatic hypermutation (SHM) and class-switch recombination (CSR) and functions by deaminating deoxycytidines (dC) to… CONTINUE READING