AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model

@article{Giri2006AICARIA,
  title={AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model},
  author={Shailendra Giri and Ramandeep Rattan and Ehtishamul Haq and Mushfiquddin Khan and Rifat Yasmin and Je-song Won and L. Lyndon Key and Avtar Kaur Singh and Inderjit Singh},
  journal={Nutrition & Metabolism},
  year={2006},
  volume={3},
  pages={31 - 31}
}
BACKGROUND Obesity is one of the principal causative factors involved in the development of metabolic syndrome. AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. The role of AMP-activated protein kinase in adipocyte differentiation is not completely understood, therefore, we examined the effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), a pharmacological activator of AMP-activated protein kinase (AMPK) on adipocyte… CONTINUE READING
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