AIB1 is a predictive factor for tamoxifen response in premenopausal women.

  title={AIB1 is a predictive factor for tamoxifen response in premenopausal women.},
  author={Sara Alkner and P. O. Bendahl and Dorthe Aamand Grabau and Kristina L{\"o}vgren and Olle St{\aa}l and Lisa Ryd{\'e}n and M{\aa}rten Fern{\"o}},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  volume={21 2},
BACKGROUND Clinical trials implicate the estrogen receptor (ER) coactivator amplified in breast cancer 1 (AIB1) to be a prognostic and a treatment-predictive factor, although results are not unanimous. We have further investigated this using a controlled randomised trial of tamoxifen versus control. MATERIALS AND METHODS A total of 564 premenopausal women were entered into a randomised study independent of ER status. Using a tissue microarray, AIB1 and ER were analysed by immunohistochemistry… CONTINUE READING
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