AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice.

@article{Kuang2004AIB1SRC3DA,
  title={AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice.},
  author={Shao-Qing Kuang and Lan Liao and Hao Zhang and Adrian V Lee and Bob O'Malley and Jianming Xu},
  journal={Cancer research},
  year={2004},
  volume={64 5},
  pages={
          1875-85
        }
}
Although the amplified in breast cancer 1 (AIB1) coactivator is amplified and overexpressed in breast cancers, its role in mammary carcinogenesis remains unknown. We demonstrate that during mammary development and tumorigenesis, the elevation of AIB1 level and its nuclear localization correlate with normal and transformed mammary epithelial proliferation, whereas its lower expression and cytoplasmic localization correlate with mammary epithelial quiescence and differentiation. In this study… CONTINUE READING

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