AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.

@article{Goettel2016AHRAI,
  title={AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.},
  author={Jeremy A Goettel and Roopali Gandhi and Jessica E. Kenison and Ada Yeste and Gopal Murugaiyan and Sharmila Sambanthamoorthy and Alexandra E. Griffith and Bonny Y. Patel and Dror S. Shouval and Howard L. Weiner and Scott B. Snapper and Francisco J. Quintana},
  journal={Cell reports},
  year={2016},
  volume={17 5},
  pages={1318-1329}
}
Existing therapies for inflammatory bowel disease that are based on broad suppression of inflammation result in variable clinical benefit and unwanted side effects. A potential therapeutic approach for promoting immune tolerance is the in vivo induction of regulatory T cells (Tregs). Here we report that activation of the aryl hydrocarbon receptor using the non-toxic agonist 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) induces human Tregs in vitro that suppress… CONTINUE READING
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