AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.

  title={AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.},
  author={Yanchao Huang and Steven H. Laval and Alexandra van Remoortere and Jacques Baudier and Chriselle Benaud and Louise V. B. Anderson and Volker Straub and Andr{\'e} M. Deelder and Rune R. Frants and Johan T den Dunnen and Katharine M. D. Bushby and Silv{\'e}re M. van der Maarel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={21 3},
Mutations in dysferlin cause limb girdle muscular dystrophy 2B, Miyoshi myopathy and distal anterior compartment myopathy. Dysferlin is proposed to play a role in muscle membrane repair. To gain functional insight into the molecular mechanisms of dysferlin, we have searched for dysferlin-interacting proteins in skeletal muscle. By coimmunoprecipitation coupled with mass spectrometry, we demonstrate that AHNAK interacts with dysferlin. We defined the binding sites in dysferlin and AHNAK as the… CONTINUE READING
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