AGuIX nanoparticles as a promising platform for image-guided radiation therapy

@inproceedings{Detappe2015AGuIXNA,
  title={AGuIX nanoparticles as a promising platform for image-guided radiation therapy},
  author={Alexandre Detappe and Sijumon Kunjachan and J. Rottmann and James L. Robar and Panagiotis Tsiamas and Houari Korideck and Olivier Tillement and Ross Berbeco},
  booktitle={Cancer nanotechnology},
  year={2015}
}
AGuIX are gadolinium-based nanoparticles developed mainly for imaging due to their MR contrast properties. They also have a potential role in radiation therapy as a radiosensitizer. We used MRI to quantify the uptake of AGuIX in pancreatic cancer cells, and TEM for intracellular localization. We measured the radiosensitization of a pancreatic cancer cell line in a low-energy (220 kVp) beam, a standard 6 MV beam (STD) and a flattening filter free 6 MV beam (FFF). We demonstrated that the… CONTINUE READING
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