AGenDA: gene prediction by cross-species sequence comparison

@article{Taher2004AGenDAGP,
  title={AGenDA: gene prediction by cross-species sequence comparison},
  author={Leila Taher and Oliver Rinner and Saurabh Garg and Alexander Sczyrba and Burkhard Morgenstern},
  journal={Nucleic acids research},
  year={2004},
  volume={32 Web Server issue},
  pages={W305-8}
}
Automatic gene prediction is one of the major challenges in computational sequence analysis. Traditional approaches to gene finding rely on statistical models derived from previously known genes. By contrast, a new class of comparative methods relies on comparing genomic sequences from evolutionary related organisms to each other. These methods are based on the concept of phylogenetic footprinting: they exploit the fact that functionally important regions in genomic sequences are usually more… CONTINUE READING

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