AGO3 Slicer activity regulates mitochondria–nuage localization of Armitage and piRNA amplification

@inproceedings{Huang2014AGO3SA,
  title={AGO3 Slicer activity regulates mitochondria–nuage localization of Armitage and piRNA amplification},
  author={Haidong Huang and YuJing Li and Keith E. Szulwach and Guoqiang Zhang and Peng Jin and Dahua Chen},
  booktitle={The Journal of cell biology},
  year={2014}
}
In Drosophila melanogaster the reciprocal "Ping-Pong" cycle of PIWI-interacting RNA (piRNA)-directed RNA cleavage catalyzed by the endonuclease (or "Slicer") activities of the PIWI proteins Aubergine (Aub) and Argonaute3 (AGO3) has been proposed to expand the secondary piRNA population. However, the role of AGO3/Aub Slicer activity in piRNA amplification remains to be explored. We show that AGO3 Slicer activity is essential for piRNA amplification and that AGO3 inhibits the homotypic Aub:Aub… CONTINUE READING
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