AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals.

@article{Fagard2000AGO1QA,
  title={AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals.},
  author={Mathilde Fagard and St{\'e}phanie Boutet and Jean Beno{\^i}t Morel and Carlo Bellini and Herv{\'e} Vaucheret},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 21},
  pages={11650-4}
}
Introduction of transgene DNA may lead to specific degradation of RNAs that are homologous to the transgene transcribed sequence through phenomena named post-transcriptional gene silencing (PTGS) in plants, quelling in fungi, and RNA interference (RNAi) in animals. It was shown previously that PTGS, quelling, and RNAi require a set of related proteins (SGS2, QDE-1, and EGO-1, respectively). Here we report the isolation of Arabidopsis mutants impaired in PTGS which are affected at the Argonaute1… CONTINUE READING
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