AGING AS A CONSEQUENCE OF MISREPAIR -- A NOVEL THEORY OF AGING

@article{Wang2009AGINGAA,
  title={AGING AS A CONSEQUENCE OF MISREPAIR -- A NOVEL THEORY OF AGING},
  author={Jicun Wang and Thomas M Michelitsch and Arne Wunderlin and Ravi Mahadeva},
  journal={Nature Precedings},
  year={2009},
  volume={4},
  pages={1-1}
}
It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’ on cellular and molecular levels, has been proposed in the damage (fault)-accumulation theory by Kirkwood 2006. However, this theory fails to explain some aging phenotypes such as fibrosis and premature aging, since terms such as ‘damage’ and ‘fault’ are not specified. Therefore we introduce here a… 
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