AGGRESCAN: method, application, and perspectives for drug design.

  title={AGGRESCAN: method, application, and perspectives for drug design.},
  author={Natalia Sanchez de Groot and Virginia Castillo and Ricardo Gra{\~n}a-Montes and Salvador Ventura},
  journal={Methods in molecular biology},
Protein aggregation underlies the development of an increasing number of conformational human diseases of growing incidence, such as Alzheimer's and Parkinson's diseases. Furthermore, the accumulation of recombinant proteins as intracellular aggregates represents a critical obstacle for the biotechnological production of polypeptides. Also, ordered protein aggregates constitute novel and versatile nanobiomaterials. Consequently, there is an increasing interest in the development of methods able… CONTINUE READING

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