AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

@article{ConchilloSol2007AGGRESCANAS,
  title={AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides},
  author={Oscar Conchillo-Sol{\'e} and Natalia S. de Groot and Francesc X. Avil{\'e}s and Josep Vendrell and Xavier Daura and Salvador Ventura},
  journal={BMC Bioinformatics},
  year={2007},
  volume={8},
  pages={1-17}
}
BackgroundProtein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases. On the biotechnological side, protein production is often hampered by the accumulation of recombinant proteins into aggregates. Thus, the development of methods to anticipate the aggregation properties of polypeptides is receiving increasing attention. AGGRESCAN is a web-based software for the prediction of aggregation-prone… CONTINUE READING
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