AGG interspersion analysis of the FMR1 CGG repeats in mental retardation of unspecific cause.

Abstract

OBJECTIVES To study the AGG interspersion pattern in mentally retarded patients of unspecified cause. METHODS FMR1 CGG substructure in 104 normal and 232 mentally retarded (MR) males was determined by CGG repeat and AGG interspersion analyses. Genomic DNA of the study subjects was obtained for PCR and Southern hybridization analyses. RESULTS All study… (More)

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