AGER -429T/C Is Associated with an Increased Lung Disease Severity in Cystic Fibrosis


The clinical course of cystic fibrosis (CF) varies between patients bearing identical CFTR mutations, suggesting the involvement of modifier genes. We assessed the association of lung disease severity with the variant AGER -429 T/C, coding for RAGE, a pro-inflammatory protein, in CF patients from the French CF Gene Modifier Study. We analyzed the lung… (More)


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@inproceedings{Beucher2012AGERI, title={AGER -429T/C Is Associated with an Increased Lung Disease Severity in Cystic Fibrosis}, author={Julie Beucher and Pierre-Yves Bo{\"{e}lle and P Busson and C{\'e}line Muselet-Charlier and Annick Cl{\'e}ment and Harriet Corvol and Michel Ab{\'e}ly and Chantal Belleguic and Georges Bellon and Katia Bessaci and A. S. Bonnel and François Br{\'e}mont and J. Brouard and Son Tung Bui and Rapha{\"{e}l Chiron and R W Chumbi-Flores and J. C. Dalphin and M. L. Dalphin and V{\'e}ronique David and Sandra Marina Ribeiro de Miranda and Jocelyne Derelle and Philippe Domblides and St{\'e}phane Dominique and J. C. Dubus and Isabelle Durieu and Sandra Dury and Madiha Ellaffi and Ralph Epaud and Annelyse Fanton and Michael Fayon and Emmanuelle Fleurence and Pascal Foucaud and J. L. Gini{\`e}s and Beno{\^i}t Godbert and Dominique Grenet and Martin Guillot and M. C. H{\'e}raud and Bruno Housset and Dominique H W Hubert and Fabien Huet and Roman Kessler and Aur{\'e}lie Labbe and Murielle Laurans and Muriel le Bourgeois and Pascal Le Roux and Carmen Llerena and G. A. Loeuille and Christophe Marguet and Laurent M{\'e}ly and Val{\'e}rie Moisan-Petit and Anne A Boerema-De Munck and Marl{\`e}ne Murris-Espin and R. Nove Josserand and J. C. Pautard and Isabelle Pin and St{\'e}phanie Pramil and Anne Pr{\'e}votat and Gilles Rault and Phillipe Reix and Natascha Remus and Michel Renouil and Martine L. Reynaud-Gaubert and B. Richaud Thiriez and Michel Roussey and Isabelle Sermet-Gaudelus and Nathalie Stremler and M. L. Uffredi and Thierry Urban and Pascale Vigneron and Beno{\^i}t Wallaert and Luk{\'a}s Weiss}, booktitle={PloS one}, year={2012} }