AGE-RAGE system and carcinogenesis.

  title={AGE-RAGE system and carcinogenesis.},
  author={Riichiro Abe and Sho-ichi Yamagishi},
  journal={Current pharmaceutical design},
  volume={14 10},
Recent clinical studies have reported an increased risk for various types of cancers in patients with diabetes. Diabetes is characterized by increased oxidative stress conditions. Hyperglycemia induces oxidative stress generation in a variety of cells via various metabolic pathways, thus causing oxidative DNA damage, an initial step of carcinogenesis. There is accumulating evidence that advanced glycation end products (AGE), senescent macroprotein derivatives formed at an accelerated rate under… CONTINUE READING


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