AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival

@article{RodriguezTeja2015AGEmodifiedBM,
  title={AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival},
  author={Mercedes Rodriguez-Teja and Julian Hendrik Gronau and Claudia Breit and Yu Zhi Zhang and Ai Minamidate and Matthew P. Caley and Afshan Mccarthy and Thomas Robert Cox and Janine Terra Erler and Luke Gaughan and Steven Darby and Craig N Robson and Francesco Angelo Mauri and Jonathan Waxman and Justin Sturge},
  journal={The Journal of Pathology},
  year={2015},
  volume={235}
}
Biomechanical strain imposed by age‐related thickening of the basal lamina and augmented tissue stiffness in the prostate gland coincides with increased cancer risk. Here we hypothesized that the structural alterations in the basal lamina associated with age can induce mechanotransduction pathways in prostate epithelial cells (PECs) to promote invasiveness and cancer progression. To demonstrate this, we developed a 3D model of PEC acini in which thickening and stiffening of basal lamina matrix… Expand
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These findings are the first to demonstrate that a CTLD acts as a suppressor and regulatory switch for EMT; thus, positing that stabilization of Endo180–CD147 complex is a viable therapeutic strategy to improve rates of prostate cancer survival. Expand
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